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Comparison of the sensitivity of PL-3994 (
), ANP (
) and CNP (
) to degradation by hNEP solution in vitro. Results are expressed as % of the starting material and are the mean or mean ± SEM of 2–5 experiments. PL-3994 was resistant to degradation by hNEP (92% remaining after 2-h exposure at 37 °C), whereas the natural ligands, ANP and CNP, were rapidly metabolized by hNEP (≤1% remaining after 2 h).
