. Author manuscript; available in PMC: 2014 Jun 25.

Published in final edited form as: Pulm Pharmacol Ther. 2012 Nov 12;26(2):229–238. doi: 10.1016/j.pupt.2012.11.001

Table 2.

Comparison of the affinities (K_is) and functional potencies (cGMP generation; EC₅₀s and E_maxs) of PL-3994, hANP and hBNP for hNPR-A, hNPR-B and hNPR-C (expressed in HEK cell lines). Results are given as the mean ± SEM.

Compound	hNPR-A					hNPR-B			hNPR-C

	Binding		Function (cGMP)			Function (cGMP)			Binding

	K_i (nm)	(n)	EC₅₀ (nm)	E_max (% hANP)	(n)	EC₅₀ (nm)	E_max (% hCNP)	(n)	K_i (nm)	(n)
PL-3994	1 ± 0.2	(45)	2 ± 0.6	95 ± 1	(57)	Not calculable	1 ± 0.5	(8)	7 ± 0.6	(4)
hANP	0.05 ± 0.01	(6)	0.4 ± 0.04	100 ± 0	(64)	Not calculable	6 ± 0.8	(5)	0.05 ± 0.03	(5)
hBNP	3 ± 1	(4)	2 ± 0.6	96 ± 2	(11)	Not calculable	9 ± 1	(7)	0.7	(2)