Table 2.
Pharmacokinetic parameters for total testosterone, free testosterone, and dihydrotestosterone after F1 and F2 administration
| Dosing | C max (ng/mL) | T max (h) | AUC(0–1,590) (ng*h/mL) | T ½ (h) |
|---|---|---|---|---|
| F1 total testosterone (ng/mL) | 5.65 ± 2.35 | 0.256 ± 0.063 | 6.41 ± 2.23 | 0.726 ± 0.165 |
| F2 total testosterone (ng/mL) | 7.84 ± 3.69* | 0.201 ± 0.043 | 8.10 ± 2.49 | 0.598 ± 0.080 |
| F1 free testosterone (pg/mL) | 36.2 ± 14.9 | 0.250 ± 0.083 | 35.1 ± 18.8 | 0.674 ± 0.187 |
| F2 free testosterone (pg/mL) | 52.4 ± 20.8* | 0.194 ± 0.054 | 55.5 ± 31.1* | 0.798 ± 0.247 |
| F1 dihydrotestosterone (ng/mL) | 0.519 ± 0.222 | 0.410 ± 0.105 | 1.39 ± 0.87 | 1.14 ± 0.49 |
| F2 dihydrotestosterone (ng/mL) | 0.578 ± 0.245 | 0.451 ± 0.066 | 1.17 ± 0.47 | 0.850 ± 0.336 |
For all calculations, the predose concentration is subtracted from the determined concentration after dosing. The values are mean ± SD. The means of F1 are calculated with the data of 13 women and the means of F2 are based on the data of 12 women
To convert total testosterone to nanomoles per liter, multiply by 3.467
AUC area under the curve, C max maximum concentration, T max time to maximum concentration, T ½ half-life
* p < 0.05, value at F2 is significantly different from F1