Table 6.

Final multiple linear regression model for z-scores of log-transformed dabigatran_trough (n = 52)

Predictora	B	SE (B)	p Value
Constant	3.99	1.08	0.001
CKD-EPI_CrCysb	−0.69	0.09	<0.001
Time between last dose and sample	−0.09	0.06	0.11
Phenytoin and phenobarbitone	−2.62	0.65	<0.001
Proton-pump inhibitor	−0.55	0.22	0.017
Amiodarone and/or verapamil	0.35	0.23	0.13
rs2244613	0.18	0.47	0.70
rs4122228	−0.13	0.47	0.79
rs8192935	0.03	0.22	0.91

Unadjusted R ² = 0.69

B unstandardised coefficients, SE standard error, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration, Cr creatinine, Cys cystatin C

^aFor all drugs, a value of 1 was assigned to those without the drug, and a value of 2 assigned to those on the drug. A value of 1 was assigned to patients who had a wildtype genotype. Patients who were heterozygous or homozygous for the single nucleotide polymorphism of interest were assigned a value of 2

^bThe z-scores of the log-transformed CKD-EPI_CrCys values