Estimated GFR using the Cockcroft–Gault equation, and modern creatinine- and cystatin C-based equations, was found to explain 32–47 % of the variability in trough steady-state dabigatran plasma concentrations between patients.

We are the first to show that co-administration of dabigatran etexilate with phenytoin and/or phenobarbitone is associated with markedly reduced dabigatran exposure.