Figure 5. 99mTc-TRODAT-1 uptake analyzed by SPECT imaging.
(A) Representative SPECT images for one monkey before (upper panels) and after (lower panels) MPTP treatment. The signal intensities in striatum were reduced after MPTP treatment. However, in the MPTP-treated animals, the right striatum showed higher signal intensities compared with the left striatum. The circled areas indicate the regions of interest. CB, cerebellum; OC, occipital cortex; Str, striatum. (B and C) The ratio of signal intensities in striatum relative to those in cerebellum and occipital cortex was measured (Str/[(CB + OC)/2]) before (B) and after (C) MPTP treatment. *P < 0.05, **P < 0.01.