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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Cardiovasc Toxicol. 2013 Dec;13(4):364–369. doi: 10.1007/s12012-013-9217-z

Figure 2. Cardiac Metalloproteinase Effects Induced by Nic and ANG II.

Figure 2

A. Activity of MMP-2 in myocardial homogenates. Exposure to Nic alone did not increase MMP-2 activity above baseline. The presence of Angiotensin II increased MMP-2 activity (*, p<0.05), which was further augmented by the presence of Nic(**, p<0.05). B. Activity of MMP-9 in myocardial homogenates. ANG II treatment significantly upregulated MMP-9 activity, but this was reduced when combined with Nic (*,** p<0.05, p<0.01, compared to control by 2-way ANOVA)..