Figure 5.

Associations of 4D and 3D differential gene signatures with lung cancer patient survival. Gene signatures of both the 4D model system (TMHRI data) and the 3D culture (Dresden data) were probed in a large compendium of human lung tumor profile datasets (n = 1492). 4D gene signatures were associated with poor overall survival in patients with lung cancer, while 3D gene signatures were associated with better overall survival. (A) Survival analysis of lung cancer patients, comparing the differences in risk between tumors, according to the degree of manifestation of the TMHRI 4D gene signature. Kaplan-Meier plot compares top third (“strong manifestation”), bottom third (“weak manifestation”), and middle third (“intermediate”); table shows correlations by univariate Cox, for each individual array dataset examined, as well as for a “compendium” of all available datasets (featured in Kaplan-Meier plot). The top third manifestation (“strong manifestation”, red) of TMHRI 4D gene signature correlated with worse survival compared to the bottom third manifestation (“weak manifestation”, blue). (B) Same as with part A, but using the Dresden 3D signature. The top third manifestation (“strong manifestation”, red) of Dresden 3D gene signature correlated with better survival compared to the bottom third (“weak manifestation”, blue).