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. Author manuscript; available in PMC: 2014 Jun 25.
Published in final edited form as: Sci Transl Med. 2013 Oct 9;5(206):206ra137. doi: 10.1126/scitranslmed.3006898

Fig. 1. PN solutions devoid of plant sterols prevent PNALD in mice.

Fig. 1

(A to D) Hepatocyte injury is indicated by elevated serum AST (A) and ALT (B) concentrations, and cholestasis is indicated by increased total bilirubin (C) and TSBAs (D) in response to infusion with SO-based PN (n = 19) in DSS-pretreated mice. DSS-pretreated mice were infused for 7 days with PN solutions containing either SO-PN or FO-PN or completely devoid of all lipids (NoL-PN). Hepatocyte injury and cholestasis were attenuated after infusion with FO-PN (n = 11) or no lipid PN (NoL-PN; n = 9), both devoid of phytosterols. Control groups consisted of DSS-pretreated mice that were infused with NS for 7 days (n = 11) or not infused at all (n = 10), in addition to completely untreated mice (no DSS, no infusion; n = 10). Means and SEM are shown. Adjusted P values were calculated with one-way ANOVA and Tukey correction for multiple comparisons. (A and D) *P < 0.0001, DSS/SO-PN versus all other groups. (B) *P < 0.0002, DSS/SO-PN versus control groups and DSS/FO-PN; P = 0.0136 versus DSS/NoL-PN. (C) *P < 0.0001, DSS/SO-PN versus control groups; P = 0.0003 versus DSS/FO-PN and DSS/NoL-PN. i.v., intravenous.