. 2014 Jun;4(2):269–279. doi: 10.1086/675990

Table 2.

Multianalyte profiling analysis data for fold change in antigen concentration

Antigen	IPAH vs. control	NIPAH vs. control	IPAH vs. NIPAH	Swiss-Prot accession no.
Adiponectin	2.4^a	2.4^a	1.0	Q15848
Beta-2 microglobulin	3.0^a	3.3^a	0.9	P23560
Creatine kinase-MB	1.9^a	1.8^a	1.1	P06732
ENRAGE	16.2^a	11.9^a	1.4	P80511
Eotaxin	1.9^a	1.8^a	1.0	P51671
Erythropoietin	7.9^a	13.6^a	0.6	P01588
Fibrinogen	1.5^a	1.4^a	1.1	P02671
GM-CSF	3.1^a	2.5^a	1.2	P04141
IL-2	6.2^a	4.9^a	1.3	P01585
IL-10	1.7^a	1.6^a	1.0	P22301
IL-16	5.1^a	4.2^a	1.2	Q14005
IL-18	2.3^a	2.2^a	1.0	AJ295724.1^*
IL-1ra	5.0^a	10.9^a	0.5	P18510
IL-5	1.9^a	1.8^a	1.1	P05113
IL-8	1.7^a	2.0^a	0.9	P10145
Lipoprotein (a)	1.6^a	2.3^a	0.7	P08519
MCP-1	2.0^a	1.9^a	1.1	P13500
MDC	1.8^a	1.4^a	1.2	O00626
MIP-1β	2.1^a	3.2^a	0.7	P13236
Myeloperoxidase	8.3^a	12.6^a	0.7	P05164
Myoglobin	2.0^a	2.0^a	1.0	P02144
MMP-9	1.4^a	3.1^a	0.5	P14780
TNF RII	2.2^a	2.6^a	0.8	Q92956
TNF-beta	3.8^a	3.4^a	1.1	P01374
Von Willebrand factor	2.4^a	2.3^a	1.1	P04275
Endothelin-1	2.8^a	1.4	2.0	P05305
G-CSF	1.5^a	1.3	1.2	P09919
IL-3	1.3^a	1.0	1.3	P08700
Complement 3	1.1	1.1^a	1.0	P01024
Cancer antigen 19–9	1.2	2.0^a	0.6	Q9BXJ9
CD40	2.0	2.2^a	0.9	Q6P2H9
Fatty acid–binding protein	4.0	4.1^a	1.0	P05413
Haptoglobin	1.0	1.5^a	0.7	P00738
IL-1α	24.5	2.2^a	11.1	P18510
Thyroid-stimulating hormone	1.3	2.6^a	0.5	P01215
Insulin	1.3	1.7^a	0.8	P01308
IL-12p40	4.2^a	2.7^a	1.6^d	P29460
IL-12p70	4.5^a	1.4^a	3.2^d	P29460
PAPP-A	3.8^a	1.7^a	2.3^d	Q13219
TNF-alpha	4.4^a	2.6^a	1.7^d	P01375
IL-13	0.6^b	0.4^b	1.4^d	P35225
Alpha-2 macroglobulin	0.5^b	0.4^b	1.4	P01023
Factor VII	0.5^b	0.6^b	0.8	P08709
Cancer antigen 125	3.6^a	13.6^a	0.3^c	Q14596
C reactive protein	7.6^a	14.5^a	0.5^c	P02741
ICAM-1	1.6^a	2.2^a	0.7^c	P05362
IgA	1.3^a	1.7^a	0.8^c	AJ222547.1^*
IL-6	88.2^a	186.1^a	0.5^c	P05231
Leptin	2.4^a	4.0^a	0.6^c	P41159
PAI-1	1.8^a	2.2^a	0.8^c	P05121
TIMP-1	1.8^a	2.2^a	0.8^c	P01033
VCAM-1	1.8^a	2.2^a	0.8^c	P19320
Alpha-1 antitrypsin	1.1	1.3^a	0.9^c	P07758
IgM	0.9	1.2^a	0.8^c	BAA12061^*
MMP-2	1.0	1.7^a	0.6^c	P08253
Serum amyloid P	0.9	1.2^a	0.8^c	P02743
Stem cell factor	0.8	1.2^a	0.7^c	P21583
Thyroxine-binding globulin	1.1	1.3^a	0.8^c	P05543
Tenascin-C	1.0	1.8^a	0.6^c	X78565.1^*
Tissue factor	1.1	2.6^a	0.4^c	P13726
VEGF	0.8	2.0^a	0.4^c	P15692
Apolipoprotein A1	0.8^b	1.0	0.8^c	P02647
SGOT	0.6^b	1.0	0.6^c	P17174
Apolipoprotein CIII	0.7^b	0.8	1.0	P02656
IGF-1	0.3^b	0.5	0.6	P01343
IL-4	0.8	0.5^b	1.7^d	P05112
Lymphotactin	1.0	0.7^b	1.4^d	P47992
IL-15	1.3^a	0.9	1.5^d	P40993

^Note

IPAH: idiopathic pulmonary hypertension; NIPAH: nonidiopathic pulmonary hypertension. ENRAGE: extracellular newly identified RAGE (receptor for advanced-glycation end products)-binding protein; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; ICAM: intracellular adhesion molecule; Ig: immunoglobulin; IGF: insulin-like growth factor; IL: interleukin; MCP: monocyte chemotactic protein; MDC: macrophage-derived chemokine; MIP: macrophage inflammatory proetin; MMP: matrix metalloproteinase; PAI: plasminogen activator inhibitor; PAPP: pregnancy-associated plasma protein; SGOT: serum glutamic oxalacetic transaminase; TIMP: tissue inhibitor of metalloproteinases; TNF: tumor necrosis factor; TNF RII: TNF receptor II; VCAM: vascular cell adhesion protein; VEGF: vascular endothelial growth factor. Asterisk indicates NCBI (National Center for Biotechnology Information) number.

Significant increase versus controls.

Significant decrease versus controls.

Significant increase in IPAH versus NIPAH patients.

Significant decrease in IPAH versus NIPAH patients.