Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun;4(2):158–168. doi: 10.1086/675978

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 by the Pulmonary Vascular Research Institute. All rights reserved.

For permission to reuse, contact journalpermissions@press.uchicago.edu.

PMC Copyright notice

In vivo molecular imaging of angiogenesis in a patient after acute myocardial infarction. Two weeks after acute myocardial infarction and percutaneous coronary intervention, a patient underwent cardiovascular magnetic resonance imaging (CMR) and positron emission tomography (PET)/computed tomography (CT). CMR gadolinium delayed contrast enhancement (DCE) was observed almost transmural in the anterior, anteriorseptal, anteriorlateral, and apical left ventricle wall (A, D). PET imaging with ¹³N-ammonia revealed impaired myocardial blood flow in correspondence with the regions of DCE (arrows; B, E). PET with the agent ¹⁸F arginine-glycine-aspartic acid peptide (¹⁸F-RGD), with affinity for the integrins, demonstrated focal signal areas in the infarcted area (C, F). This signal may reflect angiogenesis within the healing area (arrows). Polar maps of myocardial blood flow assessed by PET with ¹³N-ammonia (G, I) show severely reduced blood flow in the distal left anterior descending coronary artery perfusion region. Co-localized ¹⁸F-RGD signal corresponded to the regions of reduced blood flow (H, J), demonstrating the extent of the integrin expression in the infarcted area. Reprinted with permission from Makowski et al.¹⁰⁷

Inline graphic — In vivo molecular imaging of angiogenesis in a patient after acute myocardial infarction. Two weeks after acute myocardial infarction and percutaneous coronary intervention, a patient underwent cardiovascular magnetic resonance imaging (CMR) and positron emission tomography (PET)/computed tomography (CT). CMR gadolinium delayed contrast enhancement (DCE) was observed almost transmural in the anterior, anteriorseptal, anteriorlateral, and apical left ventricle wall (A, D). PET imaging with ¹³N-ammonia revealed impaired myocardial blood flow in correspondence with the regions of DCE (arrows; B, E). PET with the agent ¹⁸F arginine-glycine-aspartic acid peptide (¹⁸F-RGD), with affinity for the integrins, demonstrated focal signal areas in the infarcted area (C, F). This signal may reflect angiogenesis within the healing area (arrows). Polar maps of myocardial blood flow assessed by PET with ¹³N-ammonia (G, I) show severely reduced blood flow in the distal left anterior descending coronary artery perfusion region. Co-localized ¹⁸F-RGD signal corresponded to the regions of reduced blood flow (H, J), demonstrating the extent of the integrin expression in the infarcted area. Reprinted with permission from Makowski et al.¹⁰⁷