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. 2014 Jun;4(2):289–299. doi: 10.1086/675992

Figure 3.

Figure 3

SU5416 attenuates vascular remodeling from Schistosoma exposure. A. Hematoxylin and eosin staining of representative samples (arrowhead: medial thickening; arrows: adventitial inflammatory cell infiltrates; scale bar: 100 μm). B, Immunofluorescence staining for α–smooth muscle actin (α-SMA; green: media) and thrombomodulin (TM; red: intima; blue: DAPI [4′,6-diamidino-2-phenylindole]; scale bars: 50 μm). C, D, Quantification of the media and intima layers. n = 5–6 animals/group; ANOVA: P < 0.001 for media, P = 0.062 for intima. A single asterisk indicates P < 0.05, a double asterisk P < 0.01, and 4 asterisks P < 0.001 by post hoc Tukey test. CMC: carboxymethylcellulose; SU: SU5416; Schisto: Schistosoma.