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. 2013 Sep;3(3):675–691. doi: 10.1086/674440

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© 2013 by the Pulmonary Vascular Research Institute. All rights reserved.

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Effects of asymmetric dimethylarginine (ADMA) on connexin 43 (Cx43) expression are mediated by the nitric oxide (NO)–cyclic guanosine monophosphate (cGMP) pathway. A, Effects of symmetric methylarginine (SDMA) and NO pathway inhibitors ADMA and N (G)-nitro-L-arginine methyl ester (L-NAME) and NO pathway activators S-nitroso-N-acetyl-d, l-penicillamine (SNAP) and 8-Br-cGMP (cGMP) on Cx43 expression and Cx43 phosphorylation (B). C, Representative examples of Western blots corresponding to A and B. One asterisk: ; two asterisks: , compared to controls; Delta: , comparisons with ADMA. .

Inline graphic — Effects of asymmetric dimethylarginine (ADMA) on connexin 43 (Cx43) expression are mediated by the nitric oxide (NO)–cyclic guanosine monophosphate (cGMP) pathway. A, Effects of symmetric methylarginine (SDMA) and NO pathway inhibitors ADMA and N (G)-nitro-L-arginine methyl ester (L-NAME) and NO pathway activators S-nitroso-N-acetyl-d, l-penicillamine (SNAP) and 8-Br-cGMP (cGMP) on Cx43 expression and Cx43 phosphorylation (B). C, Representative examples of Western blots corresponding to A and B. One asterisk: ; two asterisks: , compared to controls; Delta: , comparisons with ADMA. .