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. 2013 Sep;3(3):675–691. doi: 10.1086/674440

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© 2013 by the Pulmonary Vascular Research Institute. All rights reserved.

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Dimethylarginine dimethylaminohydrolase I gene knockout (DDAHI KO) induces pulmonary endothelial dysfunction in vitro and in vivo. DDAHI KO in murine pulmonary microvascular cells (PMVECs) results in inhibition of gap junctional communication (A), increase in endothelial permeability (B), and inhibition of endothelial tube formation (C). D, Rotigaptide attenuates pulmonary endothelial permeability in lungs of DDAHI KO mice. One asterisk: ; two asterisks: , comparisons with controls. . AdGFP: adenoviruses for overexpression of green fluorescent protein.

Inline graphic — Dimethylarginine dimethylaminohydrolase I gene knockout (DDAHI KO) induces pulmonary endothelial dysfunction in vitro and in vivo. DDAHI KO in murine pulmonary microvascular cells (PMVECs) results in inhibition of gap junctional communication (A), increase in endothelial permeability (B), and inhibition of endothelial tube formation (C). D, Rotigaptide attenuates pulmonary endothelial permeability in lungs of DDAHI KO mice. One asterisk: ; two asterisks: , comparisons with controls. . AdGFP: adenoviruses for overexpression of green fluorescent protein.