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. 2013 Sep;3(3):578–588. doi: 10.1086/674337

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© 2013 by the Pulmonary Vascular Research Institute. All rights reserved.

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Caspase 3 activity was determined in endothelial cells incubated for 24 hours with TAK-242 or vehicle followed by treatment with lipopolysaccharide (LPS) or vehicle for an additional 4 hours ( for each group). The vehicle for TAK-242 was dimethyl sulfoxide diluted 1∶1,000 with phosphate-buffered saline. LPS-mediated apoptosis was reduced to baseline in cells treated with TAK-242 (). TAK-242 treatment by itself did not affect apoptosis relative to vehicle control (bar 3). n values appear in the bars. ANOVA: analysis of variance.

Inline graphic — Caspase 3 activity was determined in endothelial cells incubated for 24 hours with TAK-242 or vehicle followed by treatment with lipopolysaccharide (LPS) or vehicle for an additional 4 hours ( for each group). The vehicle for TAK-242 was dimethyl sulfoxide diluted 1∶1,000 with phosphate-buffered saline. LPS-mediated apoptosis was reduced to baseline in cells treated with TAK-242 (). TAK-242 treatment by itself did not affect apoptosis relative to vehicle control (bar 3). n values appear in the bars. ANOVA: analysis of variance.