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. 2013 Sep;3(3):578–588. doi: 10.1086/674337

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© 2013 by the Pulmonary Vascular Research Institute. All rights reserved.

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Tumor necrosis factor α (TNF-α) induction by lipopolysaccharide (LPS) is blunted by hypoxia preconditioning. Pulmonary artery endothelial cells (PAECs) were cultured in conditions of normoxia or hypoxia for 24 hours followed by normoxia with vehicle or LPS for an additional 24 hours ( for all groups). LPS increases the expression of TNF-α in endothelial cells kept in normoxic conditions (). Pretreatment with hypoxia for 24 hours prior to LPS leads to reduced LPS-mediated TNF-α levels (). ANOVA: analysis of variance.

Inline graphic — Tumor necrosis factor α (TNF-α) induction by lipopolysaccharide (LPS) is blunted by hypoxia preconditioning. Pulmonary artery endothelial cells (PAECs) were cultured in conditions of normoxia or hypoxia for 24 hours followed by normoxia with vehicle or LPS for an additional 24 hours ( for all groups). LPS increases the expression of TNF-α in endothelial cells kept in normoxic conditions (). Pretreatment with hypoxia for 24 hours prior to LPS leads to reduced LPS-mediated TNF-α levels (). ANOVA: analysis of variance.