Figure 1.

Increased endothelial permeability and impaired interendothelial junctional integrity in mouse lung endothelium acutely depleted of intersectin-1s (ITSN-1s); representative electron micrographs showing open interendothelial junctions (IEJs) labeled throughout their length by 8-nm gold albumin (Au-BSA) particles. Arrows in A (magnified in a1) point to three or four Au-BSA particles located close to each other in the same plan, indicative of the wide opening of the IEJ. Gold particles are also associated with the abluminal exit of IEJs. Note also the limited number of caveolae and the dilation of the pericapillary space (asterisks). pvs: perivascular space; siRNA: small interfering RNA. Scale bars: 200 nm (A), 100 nm (B).