Figure 7.

Narcotics use to control infusion site pain was modest. We asked patients to record the number of doses of any narcotic taken specifically for subcutaneous treprostinil infusion site pain; 16 subjects reported narcotics use in 103/203 diaries (conversely, 100 diaries did not document any narcotics use despite having access to a narcotics prescription). In A, the number of patients using any narcotic on day 3 (the day of worst pain as illustrated in Fig. 3) is shown. We routinely prescribe hydrocodone/acetaminophen 5 mg/500 mg, and thus, that is the drug whose use is most commonly documented. We further analyzed the number of hydrocodone tablets taken on day 3 (B). Most patients took 3 tablets or less on the day that was, on average, the most painful. The rigorous analysis described in the text shows that subjects recorded significantly more pain in the diaries for which they also recorded narcotics use.