Table 2.
Transcripts altered ≥1.5-fold in sham-operated C57BL/6 mice that were treated with GW0742
| Symbol | Probe ID | Accession no. | Definition | FC | P |
|---|---|---|---|---|---|
| Egr2 | ILMN_2623983 | NM_010118.1 | Early growth response 2 | 4.18 | 1.52 × 10−5 |
| Errfi1 | ILMN_2714031 | NM_133753.1 | ERBB receptor feedback inhibitor 1 | 3.38 | 5.29 × 10−5 |
| Angptl4 | ILMN_2759365 | NM_020581.1 | Angiopoietin-like 4 | 3.22 | 6.75 × 10−4 |
| Erg1 | ILMN_2662926 | NM_007913.5 | Early growth response 1 | 2.71 | 1.03 × 10−6 |
| Slc41a3 | ILMN_3154553 | NM_001037493.1 | Solute carrier family 41, member 3 (Slc41a3), transcript variant 2 | 2.42 | 2.06 × 10−2 |
| Fos | ILMN_2750515 | NM_010234.2 | FBJ osteosarcoma oncogene | 2.23 | 1.49 × 10−3 |
| Junb | ILMN_1220034 | NM_008416.1 | Jun-B oncogene (Junb) | 2.20 | 9.81 × 10−5 |
| Cyr61 | ILMN_2794645 | NM_010516.1 | Cysteine-rich protein 61 | 2.19 | 6.99 × 10−4 |
| Cyr61 | ILMN_2710253 | NM_010516.1 | Cysteine-rich protein 61 | 2.18 | 2.30 × 10−4 |
| Fosb | ILMN_2778279 | NM_008036.2 | FBJ osteosarcoma oncogene B | 1.87 | 1.03 × 10−6 |
| Nfkbiz | ILMN_2755008 | NM_030612.2 | Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta | 1.87 | 1.89 × 10−3 |
| Clock | ILMN_2610973 | NM_007715.5 | Circadian locomoter output cycles kaput | 1.57 | 1.84 × 10−4 |
| Slc41a3 | ILMN_3075513 | NM_001037493.1 | Solute carrier family 41, member 3, transcript variant 2 | 1.56 | 2.07 × 10−2 |
| Zfp36 | ILMN_3162407 | NM_011756.4 | Zinc finger protein 36 (Zfp36) | 1.54 | 2.84 × 10−2 |
| Podn | ILMN_1229370 | NM_172874.2 | Podocan | 0.66 | 1.89 × 10−3 |
| Prei4 | ILMN_2601884 | NM_001042671.1 | Mus musculus preimplantation protein 4, transcript variant 3 | 0.57 | 8.94 × 10−3 |
| EG241041 | ILMN_2911009 | NR_002858.1 | Predicted gene, EG241041 on chromosome 1 | 0.50 | 1.52 × 10−3 |
| Prei4 | ILMN_1251682 | NM_001042672.1 | Preimplantation protein 4 (Prei4), transcript variant 4 | 0.48 | 1.52 × 10−5 |
| Coq10b | ILMN_3031099 | NM_001039710.1 | Coenzyme Q10 homolog B (S. cerevisiae) (Coq10b), transcript variant 1 | 0.47 | 1.89 × 10−3 |
| 2210407C18Rik | ILMN_1226767 | NM_144544.1 | RIKEN cDNA 2210407C18 gene | 0.38 | 5.76 × 10−5 |
Note
Animals were sham operated and treated with placebo (vehicle) or 30 mg/kg/d GW0742. After 14 days, the right ventricle was excised, and RNA was extracted from each sample. Gene expression was measured using the Illumina MouseRef-8v3 BeadChip array, and data were analyzed using the syntax package R (ver. 2.3.1) with Bioconductor and limma. Genes that were significantly altered were calculated using a moderated t test followed by Benjamini-Hochberg false-discovery rate correction. FC: fold change.