Table 2.
Pretransplant right heart catheterization (RHC) data
| RHC date, test | RAP, mmHg | RVP, mmHg | PAP, mmHg | PCWP, mmHg | TPG, mmHg | PA sat, % | CI | PVRI, WU × m2 | Therapy |
|---|---|---|---|---|---|---|---|---|---|
| Jan 29, 2008 | Sildenafil | ||||||||
| Baseline | 9 | 61/10 | 60/23 (38) | 4 | 34 | 53 | 4.4 | 7.7 | |
| 100% O2 | 9 | 56/0 | 58/22 (36) | 7 | 29 | 80 | 4.5 | 6.5 | |
| 100% O2 + iNO 80 ppm | 9 | 50/1 | 40/14 (25) | 8 | 17 | 83 | 6.32 | 2.9 | |
| Jan 11, 2010 | Sildenafil and bosentan | ||||||||
| Baseline on 2L | 4 | 81/10 | 81/27 (45) | 4 | 41 | 70 | 3.8 | 10 | |
| 100% O2 | 71/26 (40) | 9 | 31 | 80 | 3.9 | 7.9 | |||
| 100% O2 + iNO 40 ppm | 68/19 (36) | 7 | 29 | 79 | 3.7 | 7.9 | |||
| Sep 3, 2010 | |||||||||
| Baseline | 15 | 102/30 (59) | 11 | 48 | 62 | 3.9 | 7.3 | Sildenafil, bosentan, and inhaled treprostinil; transitioned to IV treprostinil |
Early RHC data demonstrate pulmonary arterial hypertension (PAH), initially responsive to oxygen and inhaled nitric oxide (iNO). RHC data after syncopal event (January 11, 2010) demonstrate that the patient was no longer significantly responsive to oxygen or nitric oxide. RHC on September 3, 2010, after a presyncopal event, shows progression of PAH. RAP: right atrial pressure; RVP: right ventricular pressure, systolic/diastolic; PAP: pulmonary arterial pressure, systolic/diastolic (mean); PCWP: pulmonary capillary wedge pressure; TPG: transpulmonary gradient; PA sat: pulmonary artery oxygen saturation; CI: cardiac index (L/min/m2) PVRI: pulmonary vascular resistance index; WU: Wood units; 2L: 2L oxygen by nasal cannula.