Table 1.
Mean pulmonary artery pressures, right ventricular hypertrophy, and pulmonary artery anatomic changes in ductus arteriosus ligation (DAL) sheep model
| Reference | Mean pulmonary artery pressure changes, mmHg | Right ventricular changes (RVH) | Pulmonary arterial anatomic changes | |||
|---|---|---|---|---|---|---|
| DAL | Control | DAL | Control | DAL | Control | |
| Grover et al.23,a | NA | NA | 0.71 ± 0.02 | 0.55 ± 0.02 | 65.4 ± 4 | 48.1 ± 3 |
| Gien et al.24,b | 77 ± 5, 79 ± 5 | 42 ± 2, 41 ± 2 | 0.82 ± 0.05 | 0.53 ± 0.03 | NA | NA |
| Belik et al.22,c | 72.3 ± 3.8 | 54.1 ± 2 | 12.5 ± 0.7 g | 6.8 ± 0.3 g | 2.2 ± 0.19 | 0.85 ± 0.06 |
| Abman et al.2,d | 62 ± 3 | 48 ± 1 | 7.4 ± 0.5 g, 0.60 ± 0.02 | 5.8 ± 0.3 g, 0.49 ± 0.01 | 76.7 ± 7.6 | 53.3 ± 2.8 |
| Jaillard et al.25,e | Day 2: 52 ± 3; day 8: 67 ± 4 | Day 2: ∼44; day 8: ∼49 | 0.75 ± 0.05 | 0.5 ± 0.04 | 17 ± 1 | 12 ± 2 |
Values are means ± SE when available. Some values are approximations of the mean based on graphs or other figures provided by the authors in the source materials, because of a lack of specific published values. RVH is expressed as 
, the weight ratio of right ventricle to (left ventricle plus septum), unless noted. Pulmonary artery anatomic changes are expressed as percent of wall thickness, (2 × wall thickness/entire vessel diameter) × 100, unless otherwise noted.
Ductus arteriosus constriction.
Two different groups described in the same study.
RVH expressed as absolute weight of RV free wall in grams. Pulmonary artery anatomic changes expressed as second- to fifth-generation pulmonary artery combined actin content in micrograms per milligram of wet tissue.
Partial DAL. RVH expressed as absolute weight and as RV/LV+S.
Measurements performed on day 2 and 8 after partial DAL or sham control operation.