Table 1.
Upregulated genes in sickle cell disease (SCD)–associated pulmonary arterial hypertension (PAH) lungs versus control non-PAH lungs
| Gene | Description | Fold change (SCD vs. control) |
|---|---|---|
| SULT6B1 | Sulfotranferase family, cystolic, 6B, member 1 | 4.50 |
| OR5AN1 | Olfactory receptor, family 5, subfamily AN, member 1 | 3.90 |
| RBFOX1 | RNA binding protein, fox 1 homolog 1 | 3.23 |
| CXCL11 | Chemokine (C-X-C motif) ligand 11 | 3.04 |
| HAS2 | Hyaluronan synthase 2 | 3.02 |
| CT45A1 | Cancer/testis antigen family 45, member A1 | 3.02 |
| G6PC | Glucose-6-phosphate, catalytic subunit | 2.99 |
| ATXN3L | Ataxin 3–like | 2.95 |
| GJA3 | Gap junction protein, alpha 3 | 2.76 |
| AWAT2 | Acyl-CoA wax alcohol acyltranferase 2 | 2.61 |