Table 2.
Downregulated genes in sickle cell disease (SCD)–associated pulmonary arterial hypertension (PAH) lungs versus control non-PAH lungs
| Gene | Description | Fold change (SCD vs. control) |
|---|---|---|
| HRCT1 | Histidine-rich carboxyl terminus 1 | 0.31 |
| DEFA4 | Defensin, alpha 4, corticostatin | 0.32 |
| ADORA3 | Adenosine A3 receptor | 0.33 |
| ARPC5 | Actin-related protein 2/3 complex, subunit 5, 16 kDa | 0.36 |
| NTM | Neurotrimin | 0.36 |
| CHRM1 | Cholinergic receptor, muscarninic 1 | 0.37 |
| CLEC1B | C-type lectin domain family 1, member B | 0.39 |
| OLFM4 | Olfactomedin 4 | 0.41 |
| TNFRSF17 | Tumor necrosis factor receptor superfamily, member 17 | 0.42 |
| ZNF365 | Zinc finger protein 365 | 0.42 |