Figure 4.
PGI2 attenuates TZG-induced calcium influx into neurons.
Notes: (A) A representative neurons’ calcium influx induced by ex vivo TZG (blue line) or TZG plus MRE-269 treatment (red line). (B) Neuronal calcium influx induced by ex vivo TZG or ACSF pretreatment before TZG administration (red line). Maximum calcium labeling (amplitude) (C) and area under curve (D) of calcium influx in individual cells after MRE-269 plus TZG and TZG treatment alone. Bars represent group means ± SEM. *Represents a significant effect of MRE-269 plus TZG compared to TZG treatment alone (P≤0.01 for both). N=10 in one slice preparation.
Abbreviations: ACSF, artificial cerebral-spinal fluid; PGI2, prostacyclin; SEM, standard error; TZG, (RS)-(tetrazol-5-yl)glycine.