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. 2014 May 21;7:57–67. doi: 10.2147/JIR.S63205

Figure 5.

Figure 5

Deletion of the COX-2 gene in myeloid cells does not prevent endogenous PGI2 dependent protection from TZG-induced neurotoxicity.

Notes: (A) The level of 6-keto prostaglandin f1α in LysMCre COX-2flox/flox mice compared with Tie2Cre COX-2flox/flox mice 12 hours after TZG injection. (B and C) PGIS- and (D and E) CD45-labeled cells in the injured striatum in LysMCre COX-2flox/flox mice 12 hours after TZG alone or NS-398 plus TZG treatment; scale bar: 150 μm. (F) Twenty-four-hour assessment of TZG-induced lesion volume in pretreated tranylcypromine, NS-398, or TZG alone animals. Bars represent group means ± SEM. *Represents a significant effect compared to all other groups (P≤0.01 for all). N=5 in all experimental groups.

Abbreviations: PGI2, prostacyclin; PGIS, prostacyclin synthase; SEM, standard error; TZG, (RS)-(tetrazol-5-yl)glycine.