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Calcium-dependent responses were determined in PAR2-transfected HeLa cells following incubation with the indicated peptides. The curves for activating peptides are similar in shape although that for KVDGTS is shifted to the right and has a lower peak calcium response as compared to SLIGRL and SLIGKVDGTS. The inverse hexapeptides, STGDVK and LRGILS were not active.
