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. 2014 Jun 25;9(6):e100148. doi: 10.1371/journal.pone.0100148

Figure 4. In vitro demethylation of primary first trimester extravillous trophoblast cells results in alterations of mRNA expression.

Figure 4

First trimester extravillous trophoblast cells treated with the demethylating agent 5-aza-2′-deoxycytidine (AZA) versus dimethyl sulfoxide (DMSO, vehicle control) showed significant alterations in mRNA expression of (A) Cadherin 11 (CDH11), (B) Collagen, type V, alpha 1 (COL5A1), (C) Neuronal Cell Adhesion Molecule 1 (NCAM1) and (D) Tissue Necrosis Factor (TNF). Values are mean ± SEM. n = 6 *p<0.05.