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. 2014 Jun 25;9(6):e100594. doi: 10.1371/journal.pone.0100594

Figure 7. Effect of alternating hepatocyte growth factor and leukemia inhibitory factor treatment on protein synthesis pathway during hypoxia.

Figure 7

Western blots of tibialis anterior homogenates from hypoxia induced atrophic mice shows activation of protein synthesis pathway after repeated alternating injections with hepatocyte growth factor and leukemia inhibitory factor (N = 13, red) compared to PBS (N = 14, dark blue). This is based on evaluation of the phosphorylation of components from the protein synthesis pathway; pPI3K [p55α] (A), pPDK1 (B), pmTOR (C), pp70S6K (D), p4E-BP1 (E) and peIF4E (F). RU = Relative Units. Error bars are SD; Statistical significance was determined by a two-tailed Student's t–test. *denotes significant (P<0.05). Data are representative of one experiment.