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. 2014 Jun 25;9(6):e100369. doi: 10.1371/journal.pone.0100369

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© 2014 Pereyra-Bonnet et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A-C) Hypomethylation of PDX1, OCT4 and NANOG proximal promoters in untreated skin fibroblasts from diabetic patients (HF1 and HF2). Lack of expression of these genes was found for untreated fibroblasts. The bars represents the average and standard deviations of three (PDX1) and two (OCT4 and NANOG) independent sequencing procedures. (D) Direct sequencing analysis for two PDX+ reprogrammed cell lines from the same diabetic patient (HF1). No tendency were found on OCT4 (E) and NANOG (F) proximal promoters. 5mC site: 5 methylation Citocine; Rep: Repetition.