Table 2. Predictors of a 30% decline in eGFR.

	Univariate model		Multivariate model
	HR (95% CI)	P value	HR (95% CI)	P value
Age (per 10 years)	1.47 (1.07–2.07)	0.018	1.71 (1.13–2.62)	0.010
Male (versus female)	0.43 (0.22–0.83)	0.012	0.28 (0.13–0.63)	0.002
Systolic blood pressure (per 10 mmHg)	1.06 (0.90–1.23)	0.455	1.07 (0.86–1.32)	0.546
Diastolic blood pressure (per 10 mmHg)	1.20 (0.94–1.53)	0.142	1.08 (0.77–1.52)	0.660
Serum albumin (per 1.0 g/dL)	0.80 (0.51–1.24)	0.317	1.32 (0.73–2.36)	0.359
Serum creatinine (per 1.0 mg/dL)	0.67 (0.18–1.98)	0.501	0.90 (0.19–3.13)	0.885
Urinary protein excretion (per 1.0 g/day)	1.03 (0.94–1.12)	0.519	1.02 (0.91–1.13)	0.673
Therapeutic interventions within 6 months after kidney biopsy
ACE inhibitor or ARB therapy	0.72 (0.26–2.99)	0.598	0.90 (0.29–3.96)	0.874
Immunosuppressive treatment
No immunosuppressive agent	Reference		Reference
Prednisolone	0.84 (0.24–2.33)	0.758	1.30 (0.33–4.21)	0.687
Prednisolone + cyclosporine	2.18 (1.09–4.42)	0.027	2.67 (1.08–6.59)	0.034
Smokers (Current/Ex-)	2.24 (1.17–4.35)	0.015	4.00 (1.87–8.79)	<0.001
Ex-smokers	1.68 (0.64–3.93)	0.273	2.23 (0.79–5.79)	0.127
Current smokers	2.68 (1.29–5.52)	0.009	7.81 (3.17–19.7)	<0.001

HR, hazard ratio; CI, confidence interval.

Data are the HR, 95% CI, and P value from Cox proportional hazard regression analyses.

“Never smoked” was used as the reference category.

Adjusted for baseline characteristics (age, sex, systolic/diastolic pressure, serum creatinine level, urinary protein, use of ACE inhibitor or ARB within 6 months after kidney biopsy, and immunosuppressive therapy within 6 months after kidney biopsy).

Abbreviations: IMN, idiopathic membranous nephropathy; ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker.