Table 2.

Clinical and kidney microanatomical features of the study cohort from 18 to 70 years old by race and hypertension status

	African American		P	White		P	P race
	Hypertensive, n = 86 (58.5)	Non-hypertensive, n = 61		Hypertensive, n = 44 (35.8)	Non-hypertensive, n = 79		<0.001
Age (years)	46 (40.8–54)	35 (26.5–42)	<0.001	49 (39–54.8)	42 (31–52)	<0.01	0.52/0.001
Men	50 (58.1)	27 (44.3)	0.43	33 (75)	43 (54.4)	0.35	0.47/0.59
BMI (kg/m2)	31.2 ± 11.4	29.9 ± 7.0	0.41	31.8 ± 10.2	29.3 ± 7.9	0.13	0.78/0.67
MAP (mmHg)	119 (114–131)	94 (91–98)	<0.001	113 (113–119)	96 (92–99)	<0.001	0.02/0.39
CAD or CVD death	47 (54.7)	13 (21.3)	0.01	25 (56.8)	15 (19.0)	<0.01	0.98/0.95
Diabetes	9 (10.5)	0	0.01	1 (2.3)	1 (1.3)	0.7	0.23/0.89
Treated hypertension	42 (48.8)	–		20 (45.5)	–		0.96/–
Nglom: men	953 558 ± 350 054	1 021 582 ± 326 581	0.41	946 339 ± 348 970	1 019 957 ± 319 696	0.34	0.93/0.98
Nglom: women	830 322 ± 234 445	920 912 ± 213 297	0.10	699 526 ± 184 651	922 265 ± 291 882	0.02	0.10/0.98
Vglom (µm3 × 106): men	8.18 (7.13–11.33)	7.04 (5.92–8.28)	0.01	7.45 (5.95–8.89)	5.75 (4.55–7.73)	0.01	0.04/0.04
Vglom: women	8.92 (5.95–10.05)	5.92 (4.80–8.03)	0.01	8.74 (6.57–9.88)	6.12 (4.62–6.97)	0.01	0.80/0.47
Glomerulosclerosis (%)	2.96 (1.29–6.85)	0.96 (0.36–2.38)	<0.001	2.64 (1.60–4.74)	1.03 (0.54–2.48)	<0.001	0.37/0.39
Cortical fibrosis	0.05 (0.02–0.11)	0.02 (0–0.08)	<0.001	0.05 (0.03–0.08)	0.02 (0.01–0.04)	<0.001	0.53/0.94
Arterial intimal thickening	0.11 (0.06–0.18)	0.02 (0–0.08)	<0.001	0.08 (0.04–0.16)	0.03 (0–0.06)	<0.001	0.10/0.66

Continuous values expressed as mean ± standard deviation if data are normally distributed, or median (25th–75th percentiles) for non-normally distributed data. Discrete values expressed as number (%).

P for race indicates probabilities of racial differences for hypertension/non-hypertension.

Significant differences are bolded.

BMI, body mass index; MAP, mean arterial pressure; CAD, coronary artery disease; CVD, cerebrovascular disease.