Table 1. Effects of forchlorfenuron (FCF) on developmental stages of Schistosoma mansoni.
Stage | FCF | 10 min | 30 min | 1 h | 3 h | 24 h | 2-3 h removeda | 24 h removeda |
---|---|---|---|---|---|---|---|---|
Adults | <100 μM | ne | ne | ne | ne | ne | ||
300 μM | ne | ne | ne | paralysis | paralysis | recovery | ||
500 μM | paralysis | paralysis | paralysis | paralysis | death | recovery | ||
Cercariae | <100 μM | ne | ne | ne | ne | ne | ||
200 μM | ne | ne | ab | paralysis | paralysis | recovery | ||
500 μM | paralysis | paralysis | paralysis | paralysis | death | recovery | ||
Miracidia | 50 μM | ab | ab | |||||
200 μM | ab | paralysis, clumping | death |
P, paralysis; ne, no effect apparent; ab, abnormal behavior (including slowed movement, lethargy).
Phenotype observed after incubation with FCF for the indicated period followed by removal of FCF and replacement with FCF-free medium.