Table 3.
Risk of AML from one interquartile range increase in air toxics exposure during each pregnancy period
| 1st trimester OR (95% CI | 2nd trimester OR (95% CI) | 3rd trimester OR (95% CI) | Entire pregnancy OR (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N Cases/Controls |
Crude+ | Adjusted* | Crude+ | Adjusted* | Crude+ | Adjusted* | Crude+ | Adjusted* | |
| 1st factor | |||||||||
| Total PAHs | 31/13535 | 0.86 | 0.88 (0.63, 1.21) | 0.95 | 0.96 (0.74, 1.24) | 1.12 | 1.13 (0.93, 1.36) | 1.03 | 1.07 (0.69, 1.65) |
| Benzo(k)fluoranthene | 32/14195 | 1.00 | 1.01 (0.82, 1.23) | 0.93 | 0.93 (0.72, 1.19) | 1.02 | 1.03 (0.87, 1.21) | 0.99 | 1.00 (0.70, 1.42) |
| Benzo(b)fluoranthene | 32/14195 | 1.02 | 1.03 (0.85, 1.25) | 0.93 | 0.94 (0.73, 1.21) | 1.03 | 1.04 (0.87, 1.23) | 1.03 | 1.05 (0.73, 1.50) |
| Benzo(a)pyrene | 32/14195 | 1.01 | 1.02 (0.86, 1.21) | 0.95 | 0.95 (0.77, 1.18) | 1.03 | 1.04 (0.90, 1.19) | 1.04 | 1.04 (0.78, 1.40) |
| Indeno(1,2,3-cd)pyrene | 31/13535 | 0.89 | 0.90 (0.66, 1.23) | 0.95 | 0.95 (0.73, 1.24) | 1.13 | 1.14 (0.93, 1.38) | 1.04 | 1.07 (0.69, 1.65) |
| Dibenz(a,h)anthracene | 31/13535 | 0.95 | 0.95 (0.78, 1.16) | 0.89 | 0.88 (0.67, 1.17) | 1.02 | 1.02 (0.86, 1.22) | 0.91 | 0.91 (0.66, 1.26) |
| Benzo(g,h,i)perylene | 31/13535 | 0.81 | 0.83 (0.56, 1.25) | 0.96 | 0.97 (0.70, 1.36) | 1.23 | 1.25 (0.98, 1.61) | 1.18 | 1.28 (0.70, 2.36) |
| 2nd factor | |||||||||
| 1,3-Butadiene | 41/17296 | 0.90 | 0.99 (0.62, 1.58) | 1.04 | 1.13 (0.73, 1.75) | 1.34 | 1.45 (0.99, 2.15) | 1.25 | 1.58 (0.81, 3.09) |
| Ethyl benzene | 36/14768 | 0.97 | 1.02 (0.70, 1.49) | 0.91 | 0.95 (0.63, 1.44) | 1.06 | 1.12 (0.79, 1.58) | 0.94 | 1.05 (0.59, 1.85) |
| Ortho-xylene | 39/15310 | 1.07 | 1.15 (0.78, 1.71) | 1.12 | 1.20 (0.81, 1.77) | 1.28 | 1.38 (0.95, 1.99) | 1.29 | 1.48 (0.88, 2.47) |
| Benzene | 41/17299 | 1.00 | 1.13 (0.64, 2.01) | 1.15 | 1.30 (0.74, 2.28) | 1.57 | 1.75 (1.04, 2.93) | 1.51 | 1.94 (0.89, 4.19) |
| Toluene | 39/15369 | 1.16 | 1.25 (0.83, 1.88) | 1.22 | 1.31 (0.88, 1.94) | 1.41 | 1.50 (1.04, 2.16) | 1.52 | 1.78 (1.03, 3.06) |
| Styrene | 36/12773 | 1.21 | 1.27 (0.92, 1.75) | 1.15 | 1.20 (0.86, 1.68) | 1.07 | 1.08 (0.92, 1.27) | 1.31 | 1.38 (0.94, 2.03) |
| Meta/para-xylene | 29/10683 | 0.99 | 1.03 (0.71, 1.51) | 1.14 | 1.20 (0.86, 1.68) | 1.30 | 1.37 (1.01, 1.85) | 1.35 | 1.51 (0.93, 2.44) |
| Perchloroethylene | 40/15891 | 0.96 | 1.02 (0.73, 1.41) | 1.03 | 1.06 (0.82, 1.38) | 1.09 | 1.11 (0.90, 1.36) | 1.06 | 1.16 (0.75, 1.80) |
| Lead | 23/12669 | 1.03 | 1.19 (0.71, 2.02) | 1.02 | 1.18 (0.69, 2.00) | 0.95 | 1.09 (0.61, 1.92) | 1.04 | 1.31 (0.66, 2.58) |
| Carbon tetrachloride | 25/9838 | 0.80 | 0.83 (0.32, 2.14) | 0.88 | 0.90 (0.37, 2.20) | 1.02 | 1.02 (0.41, 2.52) | 0.90 | 0.92 (0.33, 2.54) |
| 3rd factor | |||||||||
| Nickel | 23/12744 | 0.96 | 1.02 (0.63, 1.67) | 1.17 | 1.23 (0.80, 1.88) | 1.05 | 1.05 (0.87, 1.28) | 1.13 | 1.21 (0.72, 2.03) |
| Chromium | 23/12737 | 0.94 | 0.99 (0.65, 1.52) | 1.05 | 1.08 (0.77, 1.53) | 0.99 | 1.02 (0.71, 1.48) | 1.01 | 1.06 (0.69, 1.62) |
| 4th factor | |||||||||
| Para-dichlorobenzene | 35/13473 | 1.12 | 1.14 (0.96, 1.35) | 1.17 | 1.19 (1.02, 1.39) | 0.68 | 0.70 (0.43, 1.14) | 1.14 | 1.19 (0.87, 1.65) |
| Chloroform | 40/16185 | 1.13 | 1.18 (0.90, 1.56) | 1.28 | 1.32 (1.04, 1.69) | 1.24 | 1.30 (1.00, 1.69) | 1.39 | 1.49 (1.07, 2.07) |
| Pollutants that did not load on a factor | |||||||||
| Formaldehyde | 39/15969 | 0.82 | 0.88 (0.62, 1.25) | 0.97 | 1.05 (0.77, 1.43) | 1.03 | 1.11 (0.83, 1.50) | 0.93 | 1.04 (0.71, 1.53) |
| Acetaldehyde | 39/15969 | 0.72 | 0.78 (0.47, 1.29) | 0.96 | 1.05 (0.67, 1.66) | 1.24 | 1.38 (0.91, 2.08) | 0.96 | 1.13 (0.64, 1.99) |
| Ortho-dichlorobenzene | 35/13419 | 0.99 | 1.04 (0.55, 1.95) | 1.16 | 1.21 (0.68, 2.15) | 1.36 | 1.45 (0.84, 2.49) | 1.30 | 1.43 (0.63, 3.23) |
| Trichloroethylene | 40/15947 | 0.91 | 0.95 (0.77, 1.17) | 0.85 | 0.89 (0.67, 1.18) | 0.94 | 0.98 (0.80, 1.21) | 0.88 | 0.92 (0.71, 1.20) |
| Selenium | 22/12189 | 0.78 | 0.76 (0.43, 1.35) | 0.98 | 0.98 (0.66, 1.46) | 1.00 | 0.99 (0.64, 1.53) | 0.89 | 0.89 (0.49, 1.60) |
+
Odds ratios adjust for birth year (matching variable)
*
Models adjusted for maternal race/ethnicity, birth year, parity, maternal birthplace, and neighborhood socioeconomic index. Included children lived within 6km of an air monitor.