Fig. 7.
Propofol attenuates the caspase-9 activation in the cortex and hippocampus of aged AD Tg mice. A) Propofol (lanes 5-8) decreases caspase-9 activation as compared to saline (lanes 1-4) in cortex of aged AD Tg mice. There is no significant difference in amounts of β-Actin in saline- or propofol-treated mice. B) Quantification of the western blot shows that propofol (black bar) attenuates the caspase-9 activation (white bar) in the cortex of aged AD Tg mice. C) Propofol (lanes 5-8) decreases caspase-9 activation as compared to saline (lanes 1-4) in hippocampus of aged AD Tg mice. There is no significant difference in amounts of β-Actin in saline- or propofol-treated mice. D) Quantification of the western blot shows that propofol (black bar) decreases caspase-9 activation as compared to saline (white bar) in the hippocampus of aged AD Tg mice. AD, Alzheimer's disease, Tg, transgenic. n = 6.