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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neurochem Int. 2013 Dec 25;0:2–8. doi: 10.1016/j.neuint.2013.12.006

Fig. 1.

Fig. 1

BCL-2 family members and those targeted by miR-29. A. The BCL-2 family is comprised of three subfamilies that contain one or more BCL-2 homology (BH) domains. The anti-apoptotic subfamily comprises proteins that contain all four BH domains. The multidomain pro-apoptotic subfamily lacks BH4 domains. Most members of these subfamilies also contain transmembrane domains (TM) and are therefore typically associated with membranes or pore formation in mitochondrial outer membranes. The BH3-only subfamily all contain the BH3 motif and most of them have no TM. The molecular weight of each protein is listed on the right (kDa). B. A single miRNA, miR-29, has many validated targets within the large BCL-2 family, including proteins in all three subfamilies.