Table 1.
Comparison of the clinicopathologic features of patients undergoing surgery for clear cell renal cell carcinoma in the analytic and validation cohorts
| Analytic cohort (n = 1378) | Validation cohort (n = 279) | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| TOPOIIa low | TOPOIIa High | p value | TOPOIIa low | TOPOIIa High | p value | |
| Gender no. (%) | 0.5515 | 0.4427 | ||||
| Female | 358 (34.2) | 120 (36.1) | 81 (33.2) | 9 (25.7) | ||
| Male | 688 (65.8) | 212 (63.9) | 163 (66.8) | 26 (74.3) | ||
| Age at surgery, yr | 0.7822 | 0.2001 | ||||
| Mean | 63.0 | 63.4 | 62.8 | 65.5 | ||
| Median | 63.9 | 64.6 | 63.6 | 67.2 | ||
| Range | 19.8–90.2 | 27.8–88.2 | 27.2–92.1 | 44.8–85.6 | ||
| Tumor size, cm | <0.0001 | 0.4366 | ||||
| Mean | 5.8 | 6.8 | 4.9 | 5.1 | ||
| Median | 5.0 | 6.0 | 4.0 | 4.5 | ||
| Range | 0.5–29.0 | 0.8–24.0 | 0.3–14.5 | 2.0–12.0 | ||
| TNM stage, no. (%) | <0.0001 | 0.9031 | ||||
| Missing | 3 | 1 | 1 | 0 | ||
| I | 681 (65.3) | 163 (49.2) | 175 (72.0) | 26 (74.3) | ||
| II | 151 (14.5) | 37 (11.2) | 32 (13.2) | 0 (0.0) | ||
| III | 208 (19.9) | 125 (37.8) | 35 (14.4) | 9 (25.7) | ||
| IV | 3 (0.3) | 6 (1.8) | 1 (0.4) | 0 (0.0) | ||
| Nuclear grade, no. (%) | <0.0001 | 0.0013 | ||||
| Missing | 0 | 0 | 1 | 0 | ||
| 1 | 93 (8.9) | 10 (3.0) | 19 (7.8) | 0 (0.0) | ||
| 2 | 518 (49.5) | 105 (31.6) | 169 (69.5) | 19 (54.3) | ||
| 3 | 398 (38.0) | 175 (52.7) | 47 (19.3) | 13 (37.1) | ||
| 4 | 37 (3.5) | 42 (12.7) | 8 (3.3) | 3 (8.6) | ||
| Coagulative tumor necrosis, no. (%) | <0.0001 | 0.8161 | ||||
| Missing | 0 | 0 | 2 | 0 | ||
| No | 876 (83.7) | 201 (60.5) | 198 (81.8) | 28 (80.0) | ||
| Yes | 170 (16.3) | 131 (39.5) | 44 (18.2) | 7 (20.0) | ||
| Sarcomatoid differentiation, no. (%) | 0.0006 | 0.4911 | ||||
| No | 1038 (99.2) | 320 (96.4) | 240 (98.4) | 34 (97.1) | ||
| Yes | 8 (0.8) | 12 (3.6) | 4 (1.6) | 1 (2.9) | ||
| SSIGN category, no. (%) | <0.0001 | 0.0772 | ||||
| Missing | 161 | 40 | 2 | 0 | ||
| 0–3 | 669 (75.6) | 157 (53.8) | 191 (78.9) | 24 (68.6) | ||
| 4–7 | 185 (20.9) | 92 (31.5) | 46 (19.0) | 8 (22.9) | ||
| 8+ | 31 (3.5) | 43 (14.7) | 5 (2.1) | 3 (8.6) | ||
TOPOIIa = type IIa topoisomerase; SSIGN = stage, size, grade, and necrosis.