Table 3.
Age-adjusted association (hazard ratio and 95% confidence interval) of high type IIa topoisomerase expression with cancer-specific death stratified by Mayo Clinic stage, size, grade, and necrosis score (analytic cohort only)
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|---|---|---|---|---|---|---|
| Low risk (SSIGN = 0–3) | Intermediate risk (SSIGN = 4–7) | High risk (SSIGN = 8–11) | ||||
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| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
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| TOPOIIa | ||||||
| Low | 1.0 (reference) | – | 1.0 (reference) | – | 1.0 (reference) | – |
| High | 3.55 (1.80–6.98) | 0.0002 | 1.52 (1.03–2.24) | 0.035 | 1.48 (0.81–2.71) | 0.20 |
SSIGN = stage, size, grade, and necrosis; HR = hazard ratio; CI = confidence interval; TOPOIIa = type IIa topoisomerase