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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Immunol. 2014 Mar 21;192(9):4221–4232. doi: 10.4049/jimmunol.1302569

Figure 6. Distinct cytokine milieus produced by LPS, MPLA and CpG-B may differentially regulate effector and memory CD8 T cell differentiation.

Figure 6

(A-E) B6 mice containing a small number of naive P14 CD8+ T cells were immunized with DC-33 alone or in combination with LPS, MPLA or CpG-B. Serum samples were collected 6 and 18 hours post immunization. Cytokine and chemokine production was measured by Luminex multiplex assay. Bar graphs show the amounts of IL-12, IFNγ, IL-6, IL-10 and IL-1β produced post immunization. (F) B6 mice containing a small number of WT or IL-12Rβ2−/− P14 CD8+ T cells were immunized with DC-33 in combination with MPLA. At day 7, the frequency of splenic Thy1.1+ P14 CD8+ T cells and their expression of KLRG1 and IL-7R were analyzed. Data shown are representative of two independent experiments.