Fig. 4.

Effects of PD98059 on KHG26792-induced hypopigmentation. Mel-Ab cells were exposed to 10 µM KHG26792 in the presence of 10 µM PD98059 for 3 days. (A) Phase contrast photographs were obtained using a digital video camera. (B) Melanin content was measured as described in Methods. Each determination was performed in triplicate, and the resulting data are shown as mean±S.D. ^**p<0.01 compared with the KHG26792-treated group.