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. 2014 Jun 12;18(3):269–278. doi: 10.4196/kjpp.2014.18.3.269

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Copyright © 2014 The Korean Physiological Society and The Korean Society of Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 8 — (row A, B): Row A, A photomicrograph of a transverse section in a rat thoracic aorta (H&E, ×540); (1) Control rat: the tunica intima lined with endothelial cells (↑), tunica media (M) is relatively thick and formed mainly of wavy acidophilic elastic laminae () and smooth muscle cells (▲). Notice tunica adventitia is thin. (2) PTZ treated rat: clumps of cells with darkly stained nuclei (↑) attached to the endothelium of tunica intima which is apparently irregular. Few of the smooth muscle cells of tunica media show foamy acidophilic cytoplasm with karyolitic nucleus (▲) or clearly vacuolated cytoplasm with peripheral flat pyknotic nucleus (↑↑). (3) PTZ-LTG treated rat: apparently regular tunica intima (↑). Most of the smooth muscle cells are nearly similar to control group, others show foamy acidophilic cytoplasm (↑↑) and few number shows vacuolated cytoplasm with deeply stained nucleus (▲). (4) LTG treated rat: tunicae of the aorta are nearly similar to the control group. Row B, A photomicrograph of a section a coronary artery of the heart (H&E, ×540); (1) Control rat: an intact endothelial lining (↑). The tunica media (M) is formed of smooth muscle fibres with rod shaped vesicular nuclei (▲). The adventitia (A) is formed of loose connective tissue. (2) PTZ treated rat: multiple vacuoles in the tunica intima and tunica media (↑). Notice adherence of blood elements to the endothelium (▲). Exudates are also seen (). (3) PTZ-LTG treated rat: few vacuolated cells are seen in tunica media (↑). (4) LTG treated rat: nearly intact tunicae.

Inline graphic — (row A, B): Row A, A photomicrograph of a transverse section in a rat thoracic aorta (H&E, ×540); (1) Control rat: the tunica intima lined with endothelial cells (↑), tunica media (M) is relatively thick and formed mainly of wavy acidophilic elastic laminae () and smooth muscle cells (▲). Notice tunica adventitia is thin. (2) PTZ treated rat: clumps of cells with darkly stained nuclei (↑) attached to the endothelium of tunica intima which is apparently irregular. Few of the smooth muscle cells of tunica media show foamy acidophilic cytoplasm with karyolitic nucleus (▲) or clearly vacuolated cytoplasm with peripheral flat pyknotic nucleus (↑↑). (3) PTZ-LTG treated rat: apparently regular tunica intima (↑). Most of the smooth muscle cells are nearly similar to control group, others show foamy acidophilic cytoplasm (↑↑) and few number shows vacuolated cytoplasm with deeply stained nucleus (▲). (4) LTG treated rat: tunicae of the aorta are nearly similar to the control group. Row B, A photomicrograph of a section a coronary artery of the heart (H&E, ×540); (1) Control rat: an intact endothelial lining (↑). The tunica media (M) is formed of smooth muscle fibres with rod shaped vesicular nuclei (▲). The adventitia (A) is formed of loose connective tissue. (2) PTZ treated rat: multiple vacuoles in the tunica intima and tunica media (↑). Notice adherence of blood elements to the endothelium (▲). Exudates are also seen (). (3) PTZ-LTG treated rat: few vacuolated cells are seen in tunica media (↑). (4) LTG treated rat: nearly intact tunicae.