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. Author manuscript; available in PMC: 2014 Jun 26.
Published in final edited form as: CNS Neurol Disord Drug Targets. 2013 May 1;12(3):381–391. doi: 10.2174/1871527311312030011

Figure 4. Molecular inhibition of miR-15b is neuroprotective against neuronal ischemia in vitro.

Figure 4

(A,B) Neuroprotection afforded by sevoflurane preconditioning is significantly decreased by transduction of miR-15b (15b) in terms of cell viability (A) and cell death (B). (C,D) Transduction with the miR-15b inhibitor (15bI) effectively promotes cell viability (C) and decreases cell death (D) following OGD. Viability and death were measured by Alamar blue uptake and LDH release. Asterisks indicate comparisons between OGD-only cultures to cultures treated with OGD and transduced with the indicated lentiviral vectors. All data are mean ± SEM, from at least three indepebdent experiments, **P<0.01; and #P<0.05 compared with transduction of either miR-15b (15b) or the inhibitor miR-15B-I (15bI).