| Lipid Metabolism |
|
|
|
|
|
| ApoA4 |
483.85 |
18651.40 |
38.55 |
0.0001 |
Lipid metabolism, chylomicron and VLDL secretion |
| ApoA1 |
254.23 |
6906.41 |
27.17 |
0.0001 |
Lipid metabolism, reverse cholesterol transport |
| ASAH1 |
14.90 |
80.51 |
5.40 |
0.0064 |
Acid ceramidase, mediates cell growth arrest, differentiation and apoptosis |
| CERS2 |
92.13 |
371.37 |
4.03 |
0.0061 |
Ceramide synthase 2, regulates cell growth |
| MTM1 |
3.10 |
59.97 |
19.36 |
0.0037 |
Lipid phosphatase that negatively regulates EGFR degradation |
| PLIN2 |
127.72 |
359.13 |
2.81 |
0.0149 |
Controls the levels of lipid droplets, regulation of colonic cell growth |
| Immune |
|
|
|
|
|
| CASP1 |
128.56 |
888.21 |
6.91 |
0.0030 |
Inflammasomes mediate activation of caspase 1 and promote secretion of IL-1beta and IL-18 |
| IL1B |
2343.32 |
6974.19 |
2.98 |
0.0926 |
Linked to intestinal disorders of inflammation in neonates |
| ICAM1 |
34.94 |
112.40 |
3.22 |
0.0280 |
Leukocyte trafficking across the endothelium |
| IL33 |
10.52 |
61.12 |
5.81 |
0.0144 |
Innate immune cell modulation, mediates Th2 immune response (parasite infections) |
| LCP1 |
14.06 |
72.14 |
5.13 |
0.0081 |
Associated with active Crohn's disease |
| NFKBIA |
373.98 |
1164.21 |
3.11 |
0.0112 |
Regulates many epithelial and immune cell functions |
| PFKFB3 |
237.61 |
621.85 |
2.62 |
0.0271 |
Gene target of PPARgamma, regulates diet induced intestine inflammation response |
| S100-A9 |
71.14 |
1192.90 |
16.77 |
0.0043 |
Calcium and zinc binding protein that regulates inflammatory and immune responses; functions extracellularly as an antimicrobial |
| SOCS3 |
164.05 |
748.63 |
4.56 |
0.0017 |
Suppressor of cytokine signaling, generally anti-inflammatory that limits IL-6 induction of STAT3 |
| TREM-1 |
15.29 |
96.78 |
6.33 |
0.0172 |
Expressed on myeloid cells (PMNs, monocytes/macrophages), increases with inflammatory diseases, linked to macrophage amplification of chronic inflammation |
| TYROBP |
153.23 |
902.38 |
5.89 |
0.0067 |
An adaptor protein associated with multiple cell surface activating receptors expressed on both lymphoid and myeloid lineages |
| Cellular Function |
|
|
|
|
|
| CEBPB |
75.39 |
290.56 |
3.85 |
0.0098 |
Transcription factor regulating keratin synthesis |
| CFLAR |
30.29 |
139.71 |
4.61 |
0.0451 |
Apoptosis regulatory protein, tissue homeostasis |
| FAM65B |
9.00 |
169.30 |
18.81 |
0.0007 |
Promotes myogenic differentiation and cytoskeletal rearrangement |
| FUBP1 |
31.78 |
110.84 |
3.49 |
0.0128 |
DNA binding protein that promotes c-myc expression |
| G0S2 |
2927.30 |
60194.00 |
20.56 |
0.0003 |
Promotes apoptosis, prevents bcl2-bax heterodimers |
| KDM5B |
32.12 |
98.30 |
3.06 |
0.0281 |
Histone demethylase, favors cell proliferation |
| MMP1 |
53.25 |
159.15 |
2.99 |
0.0392 |
Matrix metalloproteinase, potential regulator of intestinal homeostasis |
| NPM1 |
59.07 |
165.49 |
2.80 |
0.0484 |
Nucleolar acidic protein, plays a positive role in cell proliferation and growth |
| SERPINA1 |
136.74 |
534.73 |
3.91 |
0.0012 |
Serine protease inhibitor, proteolytic activity towards insulin, protects lower respiratory tract |
