Table 1.
List of ODE model parameters, their descriptions, and values
Parameter | Description | Value |
---|---|---|
Sa |
Activator scale of action |
Logarithmically sampled from [10−3, 103] |
Si |
Inhibitor scale of action |
Logarithmically sampled from [10−4, 102] |
α |
Stoichiometry parameter |
Linearly sampled from [0.2, 5] |
β |
Stoichiometry parameter |
Linearly sampled from [0.2, 5] |
θa |
Activator production rate |
300, 1500 or 7500/hr |
θi |
Inhibitor production rate |
300, 1500 or 7500/hr |
γ0 |
Dilution rate constant |
0.46/hr |
ta |
Activator half-life |
5, 30, 120 or ∞ min |
γa |
Activator degradation rate constant |
ln(2)/ta |
ti |
Inhibitor half-life |
5, 30, 120 or ∞ min |
γi |
Inhibitor degradation rate constant |
ln(2)/ti |
N |
Network copy number |
1 or 2 |
λa |
Activator basal production coefficient |
0.20 |
λi |
Inhibitor basal production coefficient |
0.20 |
g | Inducer strength | 10-2+0.025C, where C = 0, 1, 2, …, 80 |