Table 4.
Associations between continuous adipose measures (per standard deviation increase) and tertiles of adipose measures with incident obesity-related cancer in the Health ABC Study
Men | Women | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
N. of people | N. cases | Event rate | Model 1 HR (95% CI) | Model 2 HR (95% CI) | N. of people | N. cases | Event rate | Model 1 HR (95% CI) | Model 2 HR (95% CI) | |
Total AT | ||||||||||
Per SD | 1171 | 82 | 7.03 | 1.11 (0.91–1.36) | 1.16 (0.93–1.44) | 1334 | 142 | 10.0 | 1.22 (1.05–1.43) | 1.23 (1.03–1.46) |
T1 | 389 | 18 | 4.84 | 1.00 | 1.00 | 444 | 38 | 8.29 | 1.00 | 1.00 |
T2 | 391 | 30 | 7.55 | 1.57 (0.87–2.81) | 1.61 (0.88–2.93) | 444 | 46 | 9.60 | 1.16 (0.75–1.78) | 1.06 (0.68–1.66) |
T3 | 391 | 34 | 8.58 | 1.78 (1.01–3.14) | 1.83 (1.00–3.36) | 446 | 58 | 12.1 | 1.44 (0.96–2.17) | 1.41 (0.91–2.19) |
P for linear trend | 0.05 | 0.06 | 0.08 | 0.11 | ||||||
VAT | ||||||||||
Per SD | 1130 | 78 | 6.90 | 1.25 (1.02–1.52) | 1.30 (1.06–1.60) | 1290 | 138 | 10.1 | 1.12 (0.96–1.32) | 1.12 (0.94–1.32) |
T1 | 376 | 13 | 3.43 | 1.00 | 1.00 | 429 | 40 | 8.64 | 1.00 | 1.00 |
T2 | 377 | 33 | 8.75 | 2.55 (1.34–4.84) | 2.86 (1.47–5.57) | 430 | 49 | 10.8 | 1.24 (0.82–1.89) | 1.29 (0.84–1.98) |
T3 | 377 | 32 | 8.55 | 2.49 (1.31–4.75) | 2.85 (1.45–5.62) | 431 | 49 | 10.8 | 1.25 (0.82–1.90) | 1.24 (0.79–1.93) |
P for linear trend | 0.008 | 0.004 | 0.31 | 0.36 | ||||||
SAT | ||||||||||
Per SD | 1109 | 75 | 6.73 | 0.97 (0.78–1.22) | 1.01 (0.80–1.27) | 1250 | 129 | 9.68 | 1.16 (0.98–1.37) | 1.16 (0.97–1.38) |
T1 | 369 | 25 | 7.13 | 1.00 | 1.00 | 416 | 36 | 8.40 | 1.00 | 1.00 |
T2 | 369 | 28 | 7.36 | 1.04 (0.61–1.78) | 1.01 (0.58–1.76) | 417 | 43 | 9.49 | 1.13 (0.72–1.76) | 1.13 (0.71–1.79) |
T3 | 370 | 22 | 5.74 | 0.81 (0.46–1.44) | 0.82 (0.46–1.49) | 417 | 50 | 11.1 | 1.31 (0.85–2.00) | 1.38 (0.88–2.17) |
P for linear trend | 0.48 | 0.52 | 0.22 | 0.16 | ||||||
Thigh IMAT | ||||||||||
Per SD | 1151 | 81 | 7.06 | 1.04 (0.83–1.28) | 0.96 (0.70–1.32) | 1310 | 139 | 9.97 | 1.12 (0.96–1.31) | 1.12 (0.95–1.31) |
T1 | 383 | 26 | 6.90 | 1.00 | 1.00 | 436 | 36 | 7.76 | 1.00 | 1.00 |
T2 | 384 | 23 | 5.70 | 0.83 (0.48–1.46) | 0.85 (0.48–1.51) | 436 | 53 | 11.6 | 1.51 (0.99–2.31) | 1.59 (1.02–2.47) |
T3 | 384 | 32 | 8.71 | 1.26 (0.75–2.11) | 1.27 (0.73–2.19) | 438 | 50 | 10.5 | 1.36 (0.88–2.08) | 1.38 (0.88–2.17) |
P for linear trend | 0.36 | 0.38 | 0.19 | 0.19 | ||||||
Thigh HU | ||||||||||
Per SD | 1151 | 81 | 7.06 | 0.96 (0.76–1.21) | 0.95 (0.75–1.21) | 1310 | 139 | 9.97 | 0.95 (0.80–1.12) | 0.94 (0.79–1.13) |
T1 | 383 | 32 | 8.74 | 1.00 | 1.00 | 436 | 49 | 10.8 | 1.00 | 1.00 |
T2 | 384 | 21 | 5.35 | 0.62 (0.36–1.07) | 0.62 (0.35–1.08) | 436 | 51 | 10.9 | 1.03 (0.70–1.53) | 0.99 (0.66–1.48) |
T3 | 384 | 28 | 7.20 | 0.83 (0.50–1.38) | 0.81 (0.50–1.38) | 438 | 39 | 8.24 | 0.78 (0.51–1.19) | 0.78 (0.50–1.22) |
P for linear trend | 0.46 | 0.42 | 0.26 | 0.28 |
Notes: Model 1 unadjusted; Model 2 adjusted for age, race, study site, education, height, smoking status, and smoking duration, comorbid conditions (cardiovascular disease, diabetes, and pulmonary disease), and physical activity. P for linear trend across tertiles from Wald statistic. AT: adipose tissue, CI: confidence interval, HR: hazard ratio, HU: Hounsfield Unit, IMAT: intermuscular adipose tissue, SAT: subcutaneous adipose tissue, SD: standard deviation, T: tertile, VAT: visceral adipose tissue