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. 2014 Jun 3;11(1):24. doi: 10.1186/1559-0275-11-24

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Copyright © 2014 Karczmarski et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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H3K27Ac is upregulated in colon carcinoma tissues. (A) Results of H3 and H3K27Ac immunostaining in 12 pairs of CRC tissues and normal mucosa and graphical depiction of densitometric assessment of differences (B). Histones were isolated from whole tissue sections by acidic extraction and equal amounts of protein were separated by SDS-PAGE, electrotransferred to PVDF membranes and immunostained with H3 (ab1791) or H3K27Ac (ab4729) antibody. Densitometric measurements were performed using OptiQuant image analysis software. H3K27Ac level was normalised to the signal from total H3. C, CRC- colon cancer; N, NC- normal colonic mucosa.