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. 2014 May 27;124(7):3032–3046. doi: 10.1172/JCI72176

Figure 4. ALDH1A1 expression is reduced in A53T transgenic mice.

Figure 4

(A) Western blot shows expression of ALDH1A1 protein in the striatum of 3 independent pairs of 2-month-old A53T transgenic and littermate nTg female mice. (B) The relative expression levels of ALDH1A1 in the striatal homogenate of 2-month-old nTg (n = 3) and A53T (n = 3) female mice. (C) Aldh1a1 mRNA expression in nigrostriatal DA neurons isolated from 2-week-old control and littermate A53T transgenic mice (n > 1,000 cells per genotype). β-Actin was used to normalize the gene expression from different samples. (D) Western blot analysis shows ALDH1A1 expression in the striatum of 1-, 6-, and 18-month-old nTg control and A53T female mice. (E) The level of ALDH1A1 expression. Four animals were used per genotype per age group. One-way ANOVA plus Tukey post test and 2-way ANOVA plus Bonferroni post test were used for data analyses. *P < 0.05, **P < 0.01, ***P < 0.001.