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. 2014 May 27;124(7):2935–2946. doi: 10.1172/JCI75157

Figure 1. Catecholamines are required for PM-induced inflammation and thrombosis.

Figure 1

We exposed wild-type (C57BL/6) mice contemporaneously to either CAPs (PM2.5) or filtered air (FA) for 8 hours daily on 3 consecutive days and measured levels of norepinephrine (NE) in the (A) BAT and (B) lung tissue. We also performed intratracheal instillations of PM (200 μg/mouse) or control (PBS) in wild-type mice and gave reserpine (5 mg/kg 100 μl) or vehicle (20% ascorbic acid 100 μl) by gavage once 4 hours before treatment with PM or control (PBS). Twenty-four hours later, we measured levels of norepinephrine in the (C) BAT, (D) adrenal gland, and (E) lung. In identically treated mice, we measured (F) IL-6 in the BALF and (G) TAT complexes in the plasma. *P < 0.05, CAPs vs. FA, PM vs. PBS; ‡ P < 0.05, reserpine vs. control.