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. 2014 Jun 17;124(7):3075–3079. doi: 10.1172/JCI71075

Figure 3. Effects of GDX/OVX and diet on BW and metabolic parameters in Kiss1r KO mice.

Figure 3

Standard chow–fed Kiss1r KO and WT and Het control females were OVX before puberty (2 weeks old; A) or just after puberty (5 weeks old; B) and weighed weekly. (C) Percent BW of week-21 Kiss1r KO and control females OVX at week 2 or week 5, relative to gonad-intact controls (assigned as 100%). (D) Fat mass in adult Kiss1r KO and WT females OVX at 2 weeks. (E) BW of gonad-intact Gnrhhpg and control female mice. (F) Percent BW of week-18 gonad-intact Gnrhhpg and Kiss1r KO females relative to gonad-intact controls from the same strains. (G and H) BW of female and male Kiss1r KO and WT mice OVX or GDX in young adulthood and challenged with HFD. Fat mass (I), GTT (J), and metabolic measures (K) of HFD-fed OVX Kiss1r KO and WT females. †P < 0.05, OVX Kiss1r KO vs. intact control; §P < 0.05, OVX Kiss1r KO vs. OVX control; #P < 0.05, OVX control vs. intact control; *P < 0.05 as indicated.