Comparison 1. Heartburn relief.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Heartburn relief: Prostigmine versus placebo	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	0.4 [0.23, 0.69]
2 Heartburn relief: Mylanta (antacid ‐ magnesium and aluminium hydroxide and simethicone) versus placebo preparation	1	156	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [1.18, 1.68]
3 Pain intensity after one week: Antacid plus ranitidine versus antacid alone	1	30	Mean Difference (IV, Fixed, 95% CI)	‐0.31 [‐1.89, 1.27]
4 Pain intensity after two weeks: Antacid plus ranitidine versus antacid alone	1	30	Mean Difference (IV, Fixed, 95% CI)	‐2.13 [‐4.37, 0.11]