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. 2014 Aug 6;4(4):20140014. doi: 10.1098/rsfs.2014.0014

Figure 1.

Figure 1.

Tumour metabolic symbiosis between oxygenated and hypoxic cells. Glucose and lactate are energy sources used in hypoxic and oxygenated cells, respectively, which is the Nash equilibrium of the metabolic symbiosis game. In the Nash equilibrium hypoxic cells generate 2 mol of ATP and 2 mol of lactate per mole of glucose, whereas aerobic cells generate 36 mol of ATP per 2 mol of lactate. (Online version in colour.)